6,9-Dihydroxy-3(15)-caryophyllen-4,8-dione--a new antibiotic from a Marasmius species.

نویسندگان

  • K Fabian
  • T Anke
  • O Sterner
چکیده

6,9-Dihydroxy-3(15)-caryophyllen-4,8-dione (1), a new cytotoxic caryophyllane sesquiterpene, was isolated from fermentations of a tropical Marasmius species. The structure was established by spectroscopic methods. 1 exhibits strong cytotoxic effects on different cell lines, but only weak antimicrobial activities. 1 weakly inhibits the incorporation of leucine and thymidine into proteins and DNA of mammalian cells and interferes with the aggregation of human and bovine platelets.

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عنوان ژورنال:
  • Zeitschrift fur Naturforschung. C, Journal of biosciences

دوره 54 7-8  شماره 

صفحات  -

تاریخ انتشار 1999